After a week off, we get our second sneak peek at the third episode of Agents of S.H.I.E.L.D.’s fourth season. The episode, titled “Uprising”, seems to deal with the dangerous illness Agent Melinda May is suffering from. A full synopsis of the episode can be found here.

You can see the sneak peek in its entirety below.

In other news this week, Agents of S.H.I.E.L.D. executive producer Jed Whedon says we may be seeing Quake’s biological father Calvin Zabo, a.k.a. Mister Hyde, finding his way back onto the show.

While we will soon see an origin story for Ghost Rider, it will not have ties to Daisy’s agro-father. “We talked about it,” EP Jed Whedon says. “We have other plans, but the temptation was there. Because we told such a deep and rich Hyde story, we feel like we do want to bring Kyle [MacLachlan] back in a different way later on.”

In the Marvel Comicverse, Mister Hyde was created by Stan Lee and Don Heck in 1963, first appearing in Journey into Mystery #99. Most recently, Mister Hyde began a drug operation in California and eventually had several run-ins with the Robbie Reyes, whom you probably know as Ghost Rider if you have tuned into AoS this season.

Agents of S.H.I.E.L.D. airs Tuesdays on ABC at 10 PM EST.

Sources: Youtube and Entertainment Weekly.