Secret Invasion just added a new lead actor in the form of Christopher McDonald, best known to general audiences as the Happy Gilmore baddie, Shooter McGavin. But McDonald has done an immeasurable amount of stuff since then which is why he has amassed a resume enough for Marvel Studios to get him cast. Deadline is reporting that McGavin’s role will be an original creation but would also have the potential for larger crossover stuff.
Last I checked, the production of Secret Invasion was eyeing middle-aged male actors for two particular roles: a counterpart role to spy boss Nick Fury and a recurring news anchor inspired by Fox News. McDonald certainly would fit the latter having seen him play insufferable jackasses though it would be cool to see him play another spy boss opposite Nick Fury. He definitely has that Silver Age Steranko look that would fit well in the MCU.